Thiol-reducing agents prevent sulforaphane-induced growth inhibition in ovarian cancer cells
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چکیده
منابع مشابه
Thiol-reducing agents prevent sulforaphane-induced growth inhibition in ovarian cancer cells
The inhibitory potential of sulforaphane against cancer has been suggested for different types of cancer, including ovarian cancer. We examined whether this effect is mediated by mitogen-activated protein kinase (MAPK) and reactive oxygen species (ROS), important signaling molecules related to cell survival and proliferation, in ovarian cancer cells. Sulforaphane at a concentration of 10 μM eff...
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Standard therapy for the treatment of ovarian cancer is radical surgery followed by radiation and/or chemotherapy using cisplatin and paclitaxel. Unfortunately, some patients relapse after this first line chemotherapy and some patients become platinum-refractory. Therefore, we analyzed two different ovarian carcinoma cell lines for their sensitivity for gamma-irradiation and treatment with cisp...
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AIM Sulforaphane (SFN), which is present in cruciferous vegetables, induces growth arrest and/or cell death in cancer of various organs. The involvement of autophagy in the SFN-induced apoptotic death of human breast cancer cells was investigated. MATERIALS AND METHODS Cell proliferation and viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and...
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ژورنال
عنوان ژورنال: Food & Nutrition Research
سال: 2017
ISSN: 1654-6628,1654-661X
DOI: 10.1080/16546628.2017.1368321